In early 2025, Evolus—yes, the same team that brought us Jeuveau—launched Evolysse, a hyaluronic acid filler line co-developed with Symatese, a French biotech company with 30+ years in tissue regeneration. Evolysse marks Evolus’ entry into the dermal filler market, and let’s just say… they’re not starting small.
The two FDA-approved products now available in the U.S.:
- Evolysse Smooth – for fine-to-moderate wrinkles and superficial correction
- Evolysse Form – for deeper volumization, structure, and support
Both fillers feature Cold-X™ Technology, which preserves the structure of hyaluronic acid in a unique way for smoother integration, long-lasting lift, and natural movement. You’re going to want to know how this changes the game.
Let’s Talk: Evolysse Smooth
Think about the areas where you want soft, elegant finesse—those nasolabial folds, marionette lines, and even areas of mild skin laxity. This is where Evolysse Smooth shines.
Key Characteristics:
- High moldability, but soft enough for dynamic areas
- Mid-to-superficial dermis placement
- Smooth extrusion force—less pressure, better precision
- Includes lidocaine for patient comfort
In clinical studies, patients showed high satisfaction at 6 and 12 months, and over 80% of subjects still had visible correction by the one-year mark. That’s a powerful data point—especially for a product that blends so naturally.
This is not your traditional mid-depth filler. Evolysse Smooth delivers high spreadability with controlled lift—ideal for those who want movement, but not motion lines.
Now Let’s Get to Evolysse Form
Evolysse Form is the workhorse. This is for mid-to-deep injections, where structure, shape, and contour matter most—cheeks, jawline, chin, temple volume, even structural support for the lower face.
What Makes It Different?
- High cohesivity = shape-holding power
- Yet still maintains injectability and flow
- Designed for areas that need projection and lift
- Also contains lidocaine
This is comparable to a Voluma or Restylane Lyft-type of product in terms of function, but the Cold-X™ crosslinking makes the behavior slightly different—it integrates faster and swells less initially. That means less post-injection downtime, and clients love that.
Why It Matters
In my clinic, the big three questions patients ask are:
- How natural will I look?
- How long will it last?
- Will I bruise and swell?
Evolysse Smooth and Form check all three boxes.
✔ Natural results due to smoother integration and adaptable rheology
✔ Longevity – FDA trials show effect lasting 9-12+ months
✔ Lower swelling, thanks to less residual BDDE and the Cold-X™ gel structure
And from an injector’s perspective? I love the ease of control during placement. The flow rate through 27G and 30G needles is excellent. It doesn’t “squirt out,” but it doesn’t fight back either.
Clinical Studies & FDA Approval
FDA approval for both products came after a robust multicenter U.S. clinical trial with over 2,000 patients globally. According to published studies and the Evolus release, patients achieved significant wrinkle reduction with low adverse event rates—on par with or better than existing HA fillers.
Let’s talk numbers:
- ≥80% patient satisfaction at 6 months
- Natural feel at rest and in motion reported in over 90% of cases
- No serious filler-related complications in studies
- Comparable durability to established HA fillers (Restylane, Juvederm)
Evolysse vs. the Competition
This will be the big question—where do Smooth and Form fit on your shelf?
| Product | Best Use | Texture | Longevity | Price Position |
|---|---|---|---|---|
| Evolysse Smooth | Moderate wrinkles, dynamic areas | Soft | ~9-12 months | Competitive |
| Evolysse Form | Deep volume, midface, jawline | Firm, cohesive | 12+ months | Competitive |
They slot in nicely alongside Juvederm and Restylane lines but give you something a bit different in terms of handling. If you’ve been a fan of Restylane Contour or RHA 3/4, you’ll like these. Especially if you’re wanting a sleeker feel and more controlled lift.
The Business Side (Because It Matters)
What is Evolysse (Evolysse) is brought to you by Evolus, a company that’s aggressively marketing to millennial and Gen Z audiences. They’ve got a reputation for keeping pricing competitive—and supporting their providers with loyalty programs and digital tools. Think Alle, but modernized.
Their injectable lineup now includes:
- Jeuveau (botulinum toxin)
- Evolysse Smooth
- Evolysse Form
And with more fillers expected in 2026 (hello lips and under eyes!), Evolus is positioning itself as the modern aesthetic injectable brand for full-face rejuvenation.
Final Thoughts
If you’re building or expanding your aesthetic practice, Evolysse is worth trialing. The Cold-X™ Technology really does make a difference in flow, feel, and recovery. It’s one of those cases where you feel the difference in the syringe and see it right after injection.
💉 Smooth gives you elegance.
💉 Form gives you structure.
Together? They give you versatility—and that’s exactly what your patients are asking for.
Pro Tip: Always layer deeper fillers like Form under lighter, softer products like Smooth. That mimics the natural anatomy and improves integration.
Let me know what you think when you try it—I’d love to hear how Evolysse is working in your hands. Join Botox Medical Training and take your Botox training certification and Evolysse Training today!
